I know I were struggling a bit, force closed on me every time I tried open the app last night. It started happening after I downloaded the 5.0 upgrade. Luckily I was able to resolve the issue. First I had to uinstall the application from my phone, download it again and finally install it one more time. Of course since this was a fresh install I had to set everything up like photo, shortner and video services again. So if your are not able to open Twidroid after upgrading, reinstall it from scratch and hopefully that will cure the problem - Worked for me anyway. Have a Nexus One running Android OS 2.2.2